2015•Zhonghua neifenmi daixie zazhiRequires access

Influence of hyperuricemia to the expression of IRS-1, IRS-2, and GLUT-4 mRNA in fat and skeletal muscle of male rats

Qian Wang, Luxia Liang

Abstract

Basic biochemical index were measured weekly in hyperuricemia rats. Real-time quantitative PCR technology was employed to measure glucose transporter-4(GLUT-4), insulin receptor substrate(IRS)-1, and IRS-2 mRNA expression in the skeletal muscle and adipose tissue. The gene expression of GLUT-4 and IRS-2 are significantly lower in the last weeks of the hyperuricemia rat. Insulin resistance caused by hyperuricemia is probably related to the lowering expression levels of GLUT-4 and IRS-2 mRNA in the target tissues. (Chin J Endocrinol Metab, 2015, 31: 902-905) Key words: Hyperuricemia; Insulin receptor substrates; Glucose transporter-4

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Hyperuricemia, Internal medicine, Endocrinology, Glucose transporter, Adipose tissue, Insulin resistance, GLUT4, Skeletal muscle