Effects of Zhibitai capsule on blood lipids, blood glucose and the adipocytokine omentin in hyperlipidemic rats

Objective To study the effect of Zhibitai capsule on blood lipids, blood glucose and omentin in hyperlipidemic rats. Methods Thirty SPF male rats were randomly divided into control group, model group and Zhibitai group.The control group was fed with common diet, while the rest rats were fed with high-fat diet.After the model was successfully established, the Zhibitai group was orally administered 8mg/kg Zhibitai capsule powder twice daily, the rats in the control group and the model group were given the same amount of normal saline respectively.After 4 weeks, the serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), blood glucose and omentin were evaluated. Results Compared with the model group, the serum levels of TC[(3.97±0.62)mmol/L vs.(6.33±1.10)mmol/L, t=5.910, P<0.01], TG[(1.51±0.47)mmol/L vs.(2.18±0.64)mmol/L, t=2.472, P<0.05]and LDL-C[(0.30±0.04)mmol/L vs.(0.48±0.16)mmol/L, t=3.451, P<0.01)]of the Zhibitai group were significantly decreased, the HDL-C level was significantly increased[(1.35±0.28)mmol/L vs.(1.06±0.31)mmol/L, t=2.195, P<0.05], blood glucose decreased significantly[(5.04±0.82)mmol/L vs.(6.43±1.10)mmol/L, t=3.204, P<0.01], and the concentration of omentin was significantly increased[(68.59±24.82)ng/L vs.(46.86±20.12)ng/L, t=2.151, P<0.05]. Conclusion Zhibitai capsule can effectively reduce the serum levels of TC, TG and LDL-C of hyperlipidemic rats and increase the content of HDL-C, effectively reduce blood sugar, and can increase the content of omentin. Key words: Hyperlipidemias; Zhibitai; Cholesterol; Triglycerides; Lipoproteins; Blood glucose; Adipokines; Rats