Influence of lithium carbonate on thyroid function in patients with bipolar affective disorder

Objective To analyze effects of lithium carbonate on thyroid function in patients with bipolar affective disorder. Methods Thirty patients with bipolar disorder and depressive episode treated in Shenzhen Kangning hospital from April 2016 to November 2017 were selected as observation group. Another 30 healthy persons in the same period were selected as control group, and the thyroid function of the two groups was compared. Results The thyroxine 4(T4), free thyroxine 3(FT3) and free thyroxine 4(FT4) in observation group were significantly lower than those in control group before treatment (P 0.05). In observation group, FT4 was significantly decreased after using lithium carbonate (P<0.05). Conclusions Lithium carbonate in the treatment of bipolar affective disorder can reduce the patients’ thyroid function in a certain degree. Key words: Bipolar affective disorder; Lithium carbonate; Thyroid function