Treatment effectiveness of intravenous rt-PA thrombolytic therapy in patients with acute cerebral infarction combined with atrial fibrillation

Objective To investigate the effect of intravenous rt-PA thrombolytic therapy on acute cerebral infarction combined with atrial fibrillation and its related factors. Methods A total of 87 patients with 10) and time from onset to treatment (0-3 h and 3.0-4.5 h). Related factors for good outcome were identified by Logistic regression analysis. Results There were no statistical differences in the NIHSS score at 24 h versus 14 d between the two groups, but the improvement of NIHSS score at 24 h and 14 d was more in thrombolysis group than in non-thrombolysis group (P 3 h after onset, intravenous rt-PA thrombolytic therapy had no significant effect on the outcome; for patients with NIHSS > 10 at admission, the NIHSS score at 24 h and 14 d, and the Rankin score (mRS) at 90 days were lower in thrombolysis group than in non-thrombolysis group (both P<0.05); for patients with rt-PA thrombolytic therapy within 3 h after onset, a better prognosis rate at the 90 days after treatment was higher in patients in the thrombolysis group than in the non-thrombolysis group. Logistic analysis showed that the prognosis was significantly correlated with NIHSS score at admission and thrombolysis treatment. Conclusions The rt-PA thrombolytic therapy can significantly improve the symptoms of patients with cerebral infarction in combination with atrial fibrillation. Severe patients (NIHSS>10) and patients with rt-PA thrombolytic therapy within 3 h of onset can benefit more from the thrombolytic therapy. The low baseline NIHSS score and the rt-PA intravenous thrombolysis therapy are the independent predictors for the good prognosis of acute ischemic stroke. Key words: Cerebral infarction; Atrial fibrillation; Thrombolytic therapy; Tissue plasminogen activator