2020•Int J ImmunolRequires access

The present situation and prospect of CAR-T cellular immunotherapy

Beilei Wang, Changsheng Li, Yixian Yang

Abstract

Cellular immunotherapy is recognized as the fourth tumor treatment after surgery, radiotherapy and chemotherapy.Chimeric antigen receptor (CAR)-T-cell therapy belongs to adoptive cellular immunotherapy.CAR-T not only has made great breakthroughs in cancer treatment, but also has good application prospects in the treatment of infectious diseases and autoimmune diseases.This article reviews the development history, clinical applications, current problems and the latest research progress of CAR-T cell immunotherapy. Key words: Chimeric antigen receptor; T cell; Immunotherapy; Tumor

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Key concepts: Chimeric antigen receptor, Immunotherapy, Medicine, Cell therapy, Radiation therapy, Immunology, Cancer immunotherapy, Immune system