Surfactant protein C gene mutations associated with children interstitial lung disease

Surfactant protein C(SP-C)is found to be expressed only in the alveolar type Ⅱ cells(AECⅡ), surfactant protein C gene mutations are found to be associated with Children interstitial lung disease.This review discusses the mechanism, diagnosis and therapy of the interstitial lung disease induced by the surfactant protein C gene mutations. Key words: Children; Interstitial lung disease; Surfactant protein C; Gene mutation