2009•Zhonghua neifenmi daixie zazhiRequires access
Role of pancreatic stellate cell activation in islet fibrosis of rats fed with high-fat
Lin Pan
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Abstract
Pancreatic stellate cell (PSC) activation in islet fibrosis of insulin-resistant rats induced by high-fat diet was investigated. After 20 weeks, the glucose infusion rate and glucose-stimulated insulin secretion in high-fat group were significantly decreased while fasting plasma glucose, fasting serum insulin, free fatty acid and the basal glucagon secretion were significantly increased compared with those parameters of the control rats (P< 0.05 or P<0.01). Activated PSC and collagen fiber ( type Ⅰ and Ⅲ) were found in islets of rats fed with high-fat. The result suggests that PSC activation, proliferation and migration to islet may contribute to islet fibrosis in insulin-resistant rats.
Key words:
High-fat diet; Insulin resistance; Pancreatic stellate cell activation; Islet fibrosis