2019•药物不良反应杂志Requires access
Anaphylaxis induced by haemocoagulase agkistrodon for injection: report of 2 cases
Yang Shi, Baolin Hou, Yonghong Cao, Dengfeng Fan, Hongxia Zhang, Xiaoli Chen
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Abstract
Two patients (patient 1, a 54-year-old male; patient 2, a 39-year-old female) received intravenous injection of haemocoagulase agkistrodon for injection (2 U, once daily) to reduce bleeding after percutaneous holmium laser lithotripsy and hysteroscopic diagnostic curettage, respectively. Patient 1 developed urticaria on the third day of treatment. Haemocoagulase agkistrodon was stopped and cured after anti allergy treatment. Patient 2 developed palpitation, dyspnea, nausea, tremor of limbs, and etc. after about 5 minutes of medication. Her body temperature was 36.6 ℃, heart rate was 88 beats/min, breath rate was 23 times/min, blood pressure was 117/63 mmHg, and erythema appeared on her limbs and chest skin. Haemo-coagulase agkistrodon was stopped and antiallergic treatments and oxygen inhalation were given. Her symptoms disappeared about 30 minutes later and the rash disappeared 1 week later. The allergic reactions in the 2 patients were considered to be caused by haemocoagulase agkistrodon.
Key words:
Batroxobin; Urticaria; Anaphylaxis