Effects of therapy of hyperbaric oxygen combined with mecobalamin on diabetic peripheral neuropathy

Objective To study effects of hyperbaric oxygen combined with mecobalamine on diabetic peripheral neuropathy(DPN)and explore effective therapeutic way to DPN.Methods Three hundred and seventy-eight patients.were divided into two groups.The treatment group(198 cases)were treated with hyperbaric oxygen(HBO)and mecobalamin(0.2 MPa,500 μg mecobalamin i.m.,once a day).The control group(180 cases)were only treated with 500 μg meeobalamin i.m.,once a day.Courses of treatment in two groups both were four weeks.Results The effective rate and overall efficacy rate of treatment group were 40.9% and 100%,respectively.They were significantly higher than those of control group(17.3% and 53.3%)(P＜0.01).At the same time,there were obvious differences in nerve conduction velocity and dvnamics of blood flow between two groups(P＜0.01).Conclusions HBO combined with mecobalamin has therapeutic effect on DPN,which may be regared as a conventional therapy. Key words: Diabetic peripheral neuropathy; Hyperbaric oxygen; Mecobalamin