2008•中国综合临床Requires access
Lipoprotein lipase activity anti its relationship to serum lipid levels in elderly
Hai-xin Zhong
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Abstract
Objective To evaluate lipoprotein lipase (LPL) activity and its relationship to serum lipid. Methods Serum triglyceride (TG) ,total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and postheparin LPL activity in 40 elderly subjects and 45 subjects in control group. Results TG,TC and LDL-C levels were much higher in the elderly than in control group (P <0.05 orP <0.01) ;postheparin LPL activity was lower in elderly (P <0.05) ; and showed a negative correlation with serum TG level (r = -0. 513 ,P < 0.01), but was positively correlated with serum HDL-C concentration (r = 0. 390, P < 0.05). Conclusion The decreased activity of LPL in the elderly may contribute to hypertriglyceridemia associated with low level of high density lipoprotein cholesterol, and could be a risk factor for atherosclerosis.
Key words:
Elderly; Lipoprotein lipase; Triglyceride; High density lipoprotein choleaterol