2009•Zhonghua neifenmi daixie zazhiRequires access
Expression of COX-2 mRNA in rat aortic endothelial cells in high glucose environment
Yingli Lu, Tingting Ye, Hua Yang, Yi Chen, Jiao Yu, Lijuan Zhao, Fangzhen Xia, Ning-jian Wang, Chao Shi, Jie Qiao, Lin Ye, Dongping Lin, Wanling Wu
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Abstract
The expression of cyclooxy genase-2 (Cox-2) in endothelial cells (ECs) was determined. These cells were from aorta of diabetic rat and SD rats, cultured in vitro with high glucose. High glucose increased COX-2 mRNA expression both in rat aortic ECs cultured in vitro and in vivo,which was inhibited by aspirin treatment.
Key words:
Aorta; Endothelial cells; High glucose; COX-2 ; Aspirin