Analysis of oncological prognosis and survival of prosthesis after surgery for distal femoral malignant tumors

Objective To investigate the oncological prognosis, prosthesis survival rate and other related factors after limb salvage surgery for distal femoral malignant bone tumors. Methods A total of 42 patients who received the surgery of resection of malignant bone tumor of distal femur and prosthesis replacement of knee joint tumor in the Second Hospital of Shanxi Medical University from January 2008 to December 2013 were retrospectively analyzed. The patient's oncological prognosis, prosthesis survival rate and related influencing factors were analyzed. Results The follow-up period was 18-97 months. Of 42 patients with malignant bone tumors, 21 cases (50%) survived without tumor, 7 cases (16%) survived with tumor, and the 5-year overall survival rate was 66%. The overall survival rate of patients with Enneking stage ⅡB tumor was 55.4%, and that of patients with stage ⅡA tumor was 75.0%, and the difference was statistically significant (χ 2=4.350, P=0.037). The survival rate of artificial prosthesis was 78.6% (22/28), the different length of osteotomy affected the survival rate of prosthesis (χ 2=4.248, P=0.039), but the different types of prosthesis did not affect the survival rate of prosthesis (χ 2=2.177, P=0.140). Conclusions The distal femoral malignant bone tumor has a good oncological prognosis after limb salvage surgery, Enneking staging is an important factor affecting the oncological prognosis. The different length of osteotomy at the distal femur affects the survival rate of the prosthesis, the longer the prosthesis, the lower the survival rate of the prosthesis. Key words: Bone neoplasms; Distal femur; Limb-salvage treatment; Prosthesis; Survival rate