Efficacy of sevoflurane and propofol anesthesia for laparoscopic cholecystectomy and dose study

Objective To observe the effect and dose of sevoflurane combined with propofol anesthesia for laparoscopic cholecystectomy. Methods A total of 120 patients undergoing laparoscopic cholecystectomy were prospectively studied. According to the random number table, the patients were divided into group A, group B, group C, and group D, with 30 cases in each group. Anesthesia program: group A of 1% propofol, group B of 2% propofol, group C of 1% propofol + sevoflurane, group D of 2% propofol + sevoflurane. The time of consciousness disappearance, the time of Narcotrend index down to 36, the dosage of propofol within 60 min, and the total dosage of propofol, heart rate (HR) and mean arterial pressure (MAP) at T0 (entering the room), T1 (intubating), T2 (incising), T3 (abdomen closing), T4 (extubation), the recovery time of spontaneous breathing, eye opening time, extubation time were compared among the four groups. Results There were statistically significant differences in the time of consciousness disappearance, the time of Narcotrend index down to 36, the dosage of propofol within 60 min, and the total dosage of propofol among the 4 groups (P 0.05). The dosage of propofol within 60 min and the total dosage of propofol were the highest in group B, the lowest in group C, there were no statistically significant differences between group A and D (P>0.05). There were no statistically significant differences in HR and MAP among the four groups at each time point (P>0.05); there were no statistically significant differences in HR at different time points in each group (P>0.05); MAP in the 4 groups at T1 were significantly lower than those at T0, and MAP in the 4 groups at T2 were significantly higher than those at T0 (P<0.05). The recovery time of spontaneous breathing, eye opening time, extubation time of group C and D were all shorter than those of group A and B (P<0.05). Conclusions Compared with propofol total intravenous anesthesia, sevoflurane combined with propofol anesthesia for laparoscopic cholecystectomy can get better wake quality, and 1% of propofol has better pharmacodynamics, which can reduce the dose of propofol. Sevoflurane combined with 1% propofol is a kind of ideal anesthesia program for laparoscopic cholecystectomy. Key words: Laparoscopic cholecystectomy; Sevoflurane; Propofol; Dose