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2013•International Journal of Dermatology and VenereologyRequires access

Bullous pemphigoid and cicatricial pemphigoid

Tie·Duerna, Ya‐Gang Zuo

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Abstract

Bullous pemphigoid (BP) and cicatricial pemphigoid (CP) share some common features.For example,they both have a predilection for the elderly,and are usually complicated by tumors.Also,some pathogenic antibodies have been identified in both patients with BP and those with CP,which are demonstrated to be deposited on the epidermal side of skin by indirect immunofluorescence test.Biological agents,such as rituximab,have been applied to the treatment of BP and CP,and shown a favorable efficacy.Mechanisms underlying the mucosal involvement in CP are thought to be associated with autoantibodies such as BP180 and laminin 332,and further research is needed to clarify the pathogenesis of CP. Key words: Pemphigoid, bullous;  Pemphigoid, benign mucous membrane;  Therapy

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What this paper is about

Bullous pemphigoid (BP) and cicatricial pemphigoid (CP) share some common features.For example,they both have a predilection for the elderly,and are usually complicated by tumors.Also,some pathogenic antibodies have been identified in both patients with BP and those with CP,which are demonstrated to be deposited on the epidermal side of skin by indirect immunofluorescence test.Biological agents,such as rituximab,have been applied to the treatment of BP and CP,and shown a favorable efficacy.Mechanisms underlying the mucosal involvement in CP are thought to be associated with autoantibodies such as BP180 and laminin 332,and further research is needed to clarify the pathogenesis of CP. Key words: Pemphigoid, bullous;  Pemphigoid, benign mucous membrane;  Therapy

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Available abstract

Bullous pemphigoid (BP) and cicatricial pemphigoid (CP) share some common features.For example,they both have a predilection for the elderly,and are usually complicated by tumors.Also,some pathogenic antibodies have been identified in both patients with BP and those with CP,which are demonstrated to be deposited on the epidermal side of skin by indirect immunofluorescence test.Biological agents,such as rituximab,have been applied to the treatment of BP and CP,and shown a favorable efficacy.Mechanisms underlying the mucosal involvement in CP are thought to be associated with autoantibodies such as BP180 and laminin 332,and further research is needed to clarify the pathogenesis of CP. Key words: Pemphigoid, bullous;  Pemphigoid, benign mucous membrane;  Therapy

Key concepts: Bullous pemphigoid, Cicatricial pemphigoid, Pemphigoid, Medicine, Autoantibody, Rituximab, Dermatology, Direct fluorescent antibody

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