2019•International journal of pediatricsRequires access

Research progress of relationship between GATA family gene mutations with congenital heart diseases

Mingxi Chen

Abstract

The GATA transcription factor family is a type of transcription regulatory factors containing zinc finger structure, in which GATA4, GATA5 and GATA6 play a key role in the process of heart development and functional maturity.A large number of studies have confirmed that the GATA transcription factor family is not only involved in the the heart development, but also its mutations are related to the occurrence of human congenital heart diseases(CHD). This article mainly reviews the relationship between GATA family with heart development, and the relationship between GATA family gene mutation with congenital heart diseases. Key words: GATA transcription factor; Congenital heart disease; Gene mutation

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: GATA4, GATA6, GATA transcription factor, Transcription factor, Medicine, GATA2, Heart disease, Gene