Effect if fast track surgery on patients with colorectal carcinoma

Objective To investigate the effect of fast track surgery on immunologic functions and clinical application in patients with colorectal carcinoma during perioperative period.Methods 60 colorectal carcinoma pa-tiens receving radical operation were randomly divided into two groups:fast track surgery group(group A,30 cases)and conventional mmmgement group(group B,30cases).Serum levels of IgA、IgM、IgG and C reaction protein(CRP) in 60 patients were assayed preoperatively and postoperatively on 1st,3rd,7th day.The postoperative hospital stay,to-tal cost during hospitalization,the time of the first flatus,overall complications were compared.Results On the post-operative 3rd day,serum levels of IgA[(1.55±0.35)g/L vs(1.22±0.40)g/L,P<0.05],IgG[(9.88 ±1.98)g/L vs(9.01±2.35)/L,P<0.05]and IgM[(0.89±0.22)g/L vs(0.81±0.30)g/L,P<0.05]in group A were significandy higher than in group B.On the postoperative 1st,3rd,7th day,serum level of CRP d1[(51±12)g/L vs (83 ±10)g/L,P<0.05],d3[(136 ±16)g/L vs(169±17)g/L,P<0.05],d7[(57±10)g/L vs(80±9)g/L,P<0.05]in group A were significantly lower than in group B.The time of the first flatus[(3.2±0.7)d vs(4.8±0.6)d,P<0.05],time of hospitalday[(7.6±1.1)d vs(9.0±0.8)d,P<0.05]and the total cost during hospitalization [(1 3250 ±l 800)￥vs(1 6356±2 315)￥,P<0.05]were also significantly lower than in group B(P<0.05).Compared with group B,there were less rate of overall complications in group A(P<0.05).Conclusion Fast track surgery mitigates the immunologic impairment of colorectal cancer patients during perioperative period,and accelerate recovery of gastrointestinal function,reduce the rate of complications and total cost during hospitalization,shorten post-operative hospital stay. Key words: Colorectal neoplasms; Immunglobin; Fast track surgery