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2009•Zhonghua neifenmi daixie zazhiRequires access

Effect of glucocorticoid on the expression of PGC-1α mRNA in brown adipose tissue and skeletal muscle of obese rats fed with high-fat diet

Xiaolei Hu, Shi JianHua, Yanping Fan, Yan-jun Miao, Yong-qi Huang

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Abstract

Real-time fluorescent quantitative PCR was used to examine PGC-1α mRNA expression in brown adipose tissue and skeletal muscle of rats. The results showed that the expression levels of PGC-1α mRNA in brown adipose tissue and skeletal muscle of obese rats were lower than those of the normal ones (all P<0.01). After high dose glucocorticoid treatment, the levels of PGC-1α mRNA expression in brown adipose tissue and skeletal muscle, both in normal and obese rats, were decreased significantly. Key words: Obesity;  PGC-1α;  Glucocorticoids;  Rats

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What this paper is about

Real-time fluorescent quantitative PCR was used to examine PGC-1α mRNA expression in brown adipose tissue and skeletal muscle of rats. The results showed that the expression levels of PGC-1α mRNA in brown adipose tissue and skeletal muscle of obese rats were lower than those of the normal ones (all P<0.01). After high dose glucocorticoid treatment, the levels of PGC-1α mRNA expression in brown adipose tissue and skeletal muscle, both in normal and obese rats, were decreased significantly. Key words: Obesity;  PGC-1α;  Glucocorticoids;  Rats

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Available abstract

Real-time fluorescent quantitative PCR was used to examine PGC-1α mRNA expression in brown adipose tissue and skeletal muscle of rats. The results showed that the expression levels of PGC-1α mRNA in brown adipose tissue and skeletal muscle of obese rats were lower than those of the normal ones (all P<0.01). After high dose glucocorticoid treatment, the levels of PGC-1α mRNA expression in brown adipose tissue and skeletal muscle, both in normal and obese rats, were decreased significantly. Key words: Obesity;  PGC-1α;  Glucocorticoids;  Rats

Key concepts: Internal medicine, Endocrinology, Skeletal muscle, Adipose tissue, Glucocorticoid, Brown adipose tissue, Messenger RNA, Biology

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Effect of glucocorticoid on the expression of PGC-1α mRNA in brown adipose tissue and skeletal muscle of obese rats fed with high-fat diet — Research Paper | ScholarLens