2012•International Journal of Dermatology and VenereologyRequires access
Histamine and histamine intolerance
Feng Li Jiang, Hua Wang
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Abstract
Histamine is a chemical mediator possessing multiple biological activities,which is degraded by diamine oxidase and histamine-N-methyltransferase in vivo.Either decreased levels or impaired activities of histamine-metabolizing enzymes and increased concentration of exogenous histamine can induce histamine accumulation and intolerance.Clinically,histamine intolerance mimics allergy with the involvement of multiple systems,which can be induced and aggravated by foods and drugs.Final diagnosis of histamine intolerance could be confirmed according to typical symptoms,improvement of symptoms by histamine-free diet and antihistamines,positive results yielded by histamine in double-blind,placebo-controlled provocation test,elevated serum histamine concentration and diminished diamine oxidase activity.
Key words:
Intolerance; Amine oxidase; Atopic dermatitis