2011•International journal of pediatricsRequires access
Research development of leukotriene receptor antagonists as treatment for children with asthma
Hong Zhang, Yun Gao, Hongxia Zhao
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Abstract
Leukotriene is a crucial inflammation medium in the process of asthma,involved in the inflammation and remodeling of airway.This article summarizes the origin,synthesis and biological activity of leukotriene in asthma.and discuss the implications of leukotriene receptor antagonists(Montelukast)for asthma in children.The randomized.double-blind and muhicenter clinical trials are needed to determine the efficacy of Montelukast in infants less than 2 years old with asthma.
Key words:
Asthma; Leukotriene; Leukotfiene receptor antagonists; Montelukast