Effect of early CRRT on correlation kidney injury in patients with severe acute pancreatitis

Objective To investigate the effects of early continuous renal replacement thempy(CRRT) on correlation kidney injury and prognosis in patients with severe acute pancreatitis(SAP). Methods According to the digital table, 40 SAP patients were randomly divided into two groups: the control group(21 cases)and CRRT treatment group(19 cases). The levels of serum creatinine, urea nitrogen, IL-1,IL-6,TNF-α, the APACHE Ⅱ score, the incidence of mechanical ventilation were compared between the two groups. Results The levels of serum creatinine, urea nitrogen were significantly lower in the CRRT group than those in the control group in day 3(t=2.836,2.952,P=0.003,0.004); The levers of IL-1,IL-6,TNF-αwere significantly lower in the CRRT group than those in the control group in day 3(t=2.376,2.414,2.197,P=0.351,0.028,0.042);The APACHE II score,incidence of mechanical ventilation, the fatality rate in the CRRT group were significantly lower than those in the control group in day 3[(20.16±5.23)points vs.(13.83±4.48)points,14 cases (66.7%)vs.6 cases(31.6%),8 cases(38.1%)vs.2 cases(14.3%),t=4.572,χ2=4.912,4.043;P=0.0329,0.027,0.044]. Conclusion Early CRRT therapy can eliminate the IL-1,IL-6 and TNF-αin SAP patients, can reduce the incidences of AKI, which may provide more clinical benefits in the early phase of SAP. Key words: Pancreatitis, acute necrotizing; Renal replacement therapy; Interleukin-1β; Interleukin-6; Tumor necrosis factor-α