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1984•Bulletin of Pharmaceutical Sciences AssiutOpen access

ENHANCED DISSOLUTION RATE OF IBUPROFEN USING SURFACTANTS AND WATER SOLUBLE CARRIERS

M. El-Shaboury, A. Nouh, Ahmed M. Abd‐ElGawad

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Abstract

The influence of some non-ionic surfactants as well as polyethylene glycol 6000 and dextrose as water soluble carrier, on the dissolution of poorly soluble drug, ibuprofen, was studied. Surfactants produced better drug release than the polyethylene glycol and dextrose with the drug carrier ratio studied. TLC and IR studied ruled out any interaction between the drug and any of the additives used. In addition, the bulkness of the drug was not affected by the amount of surfactants added, as being found with dextrose and polyethylene glycol 6000.

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The influence of some non-ionic surfactants as well as polyethylene glycol 6000 and dextrose as water soluble carrier, on the dissolution of poorly soluble drug, ibuprofen, was studied. Surfactants produced better drug release than the polyethylene glycol and dextrose with the drug carrier ratio studied. TLC and IR studied ruled out any interaction between the drug and any of the additives used. In addition, the bulkness of the drug was not affected by the amount of surfactants added, as being found with dextrose and polyethylene glycol 6000.

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Available abstract

The influence of some non-ionic surfactants as well as polyethylene glycol 6000 and dextrose as water soluble carrier, on the dissolution of poorly soluble drug, ibuprofen, was studied. Surfactants produced better drug release than the polyethylene glycol and dextrose with the drug carrier ratio studied. TLC and IR studied ruled out any interaction between the drug and any of the additives used. In addition, the bulkness of the drug was not affected by the amount of surfactants added, as being found with dextrose and polyethylene glycol 6000.

Key concepts: Polyethylene glycol, Dissolution, Ibuprofen, Chemistry, Drug carrier, Polyethylene, Drug, Ionic bonding

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