2020•PubMedOpen access

Effect of Vitamin K Epoxide Reductase Complex 1 Polymorphism on Warfarin Dose Requirement among Patients in Tertiary Care Hospital.

Sahana Hadihalli Veeregowda, Bhuvana Krishnaswamy, Sharath Balakrishna

Abstract

BACKGROUND: polymorphism on the maintenance dose of warfarin. MATERIALS AND METHODS: gene polymorphism and warfarin maintenance dose was analyzed. RESULTS: = 0.0001). CONCLUSION: polymorphism alone influence 26.3% variability in warfarin dose and AA genotype patients required lower dose.

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Key concepts: VKORC1, Vitamin K epoxide reductase, Warfarin, Genotyping, Genotype, CYP2C9, Internal medicine, Gastroenterology