2018•PubMedRequires access

[Effect of cigarette smoke exposure on the expression of CCR7 and levels of Th1/Th2 cytokines in asthmatic rats].

Wen‐Ming Cao, Ya-ming Du, Yingcen Li, Xiuming Wu, A Z Zhang

Abstract

Cigarette smoke could enhance the expression of CCR7 and its ligand, and it can also result in exacerbations of asthma by reducing the expression level of IFN-γ (the representative of Th1 cytokine) and increasing the expression level of IL-4 (the representative of Th2 cytokine).

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Available abstract

Key concepts: Ovalbumin, Bronchoalveolar lavage, Medicine, Asthma, Immunology, C-C chemokine receptor type 7, Lung, CC chemokine receptors