[Prevalence of Hepatitis B Surface Antigens and Hepatitis B Surface Antibodies in 1-12 Years-old Children in Mianyang,Sichuan].

OBJECTIVE: To determine the prevalence of hepatitis B surface antigens (HBsAg) and hepatitis B surface antibodies (anti-HBs) in 1-12 years-old children in Mianyang city,Sichuan Province. METHODS: Children born after the implementation of Hepatitis B immunization policy were selected using a stratified random cluster sampling strategy from January to December 2015. A total of 72 623 eligible children participated in the study,which included a questionnaire survey and blood tests (0.3 mL vein blood) for HBsAg and anti-HBs with ELISA method. Repeated tests were performed on the blood samples with a HBsAg positive result. RESULTS: <0.001). About 35.37% of the children who had negative HBsAg and anti-HBs had not received Hepatitis B immunization. CONCLUSION: Hepatitis B vaccinations are highly effective in Mianyang. However,there are disparities in anti-HBs positive rates between the children with different characteristics. A certain proportion of children are still susceptible to hepatitis B infection. It is necessary to attach importance to neonatal hepatitis B vaccination,surveillance on anti-HBs,and strengthened immunization for the children who are lack of antibody protection.