2019•PubMedRequires access

[Instability of Mitochondrial DNA D-loop Region Genes in Patients with Leukemia].

Jing Wang, Yongan Zhou, Liping Su, Feng‐Min Li, Ming Chen

Abstract

OBJECTIVE: To study the instability of mitochondrial DNA（mt DNA） D-loop region genes in patients with Leukemia. METHODS: The HV-1 and HV-2 regions of D-loop region in 24 patients with leukemia were amplificated and sequenced, then their results were compared with revised Cambridge reference sequence (rCRS) and Databank mtDB. The mutation rate was detected by SPSS 22.0 statistics software. RESULTS: respectively (P＞0.05). CONCLUSION: The more high mutation rate and many kinds of mutation types exist in D-loop region, suggesting that the genes in D-loop region display the more strong instability, the chemotherapy may aggravate the instability of genes in D-loop region.

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Key concepts: D-loop, Mutation rate, Mutation, Mitochondrial DNA, Gene, Loop (graph theory), Leukemia, Biology