2019•PubMedRequires access

[Effects of combined transplantation of rat Schwann cells and fibroblasts on nerve regeneration of denervated perforator flaps in rats and the mechanism].

W Chen, Zhongya Wei, Bilian Wu, Chen‐Chia Yang, Wook Jin, Feiyu Gong, Guangfeng Sun, K Y Nie, D L Wang

Abstract

The combined transplantation of Fbs and Schwann cells in rats can regulate Schwann cells migration and clustering by activating Ephrin/Eph-Sox2-N-cadherin signaling pathway, thus promoting the orderly nerve regeneration of denervated perforator flaps in rats.

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Key concepts: Schwann cell, Transplantation, Fetal bovine serum, Sciatic nerve, Biology, Regeneration (biology), Nerve guidance conduit, Andrology