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Gene Targeting of Retinoid Receptors

David Lohnes

Open publisher page 1 citations

Abstract

Gene targeting in embryonic stem (ES) cells is a powerful technique for the modification of the mouse genome ( 1 – 3 ). Regarding the retinoid receptors, a number of laboratories have reported the phenotype of mice in which a given retinoic acid receptor (RAR) or retinoid X receptor (RXR) has been inactivated by this technique ( 14 – 12 ). In addition, a number of cellular retinoid-binding protein-null mice have also been generated ( 13 – 15 ). These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

About this research paper

What this paper is about

Gene targeting in embryonic stem (ES) cells is a powerful technique for the modification of the mouse genome ( 1 – 3 ). Regarding the retinoid receptors, a number of laboratories have reported the phenotype of mice in which a given retinoic acid receptor (RAR) or retinoid X receptor (RXR) has been inactivated by this technique ( 14 – 12 ). In addition, a number of cellular retinoid-binding protein-null mice have also been generated ( 13 – 15 ). These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Available abstract

Gene targeting in embryonic stem (ES) cells is a powerful technique for the modification of the mouse genome ( 1 – 3 ). Regarding the retinoid receptors, a number of laboratories have reported the phenotype of mice in which a given retinoic acid receptor (RAR) or retinoid X receptor (RXR) has been inactivated by this technique ( 14 – 12 ). In addition, a number of cellular retinoid-binding protein-null mice have also been generated ( 13 – 15 ). These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Key concepts: Retinoid, Retinoid X receptor, Retinoid X receptor alpha, Retinoid X receptor beta, Retinoid X receptor gamma, Retinoic acid, Receptor, Biology

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