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Pluronic Polyols—Cell Protection

David W. Murhammer

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Abstract

Abstract Pluronic polyols, especially Pluronic F‐68, are commonly added to cell culture media to protect insect and mammalian cells from the hydrodynamic stress resulting from sparging. This article describes the relevant properties of Pluronic polyols, the ability of Pluronic polyols to protect insect and mammalian cells from sparging and agitation, and the application of Pluronic polyols to cell culture.

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What this paper is about

Abstract Pluronic polyols, especially Pluronic F‐68, are commonly added to cell culture media to protect insect and mammalian cells from the hydrodynamic stress resulting from sparging. This article describes the relevant properties of Pluronic polyols, the ability of Pluronic polyols to protect insect and mammalian cells from sparging and agitation, and the application of Pluronic polyols to cell culture.

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Available abstract

Abstract Pluronic polyols, especially Pluronic F‐68, are commonly added to cell culture media to protect insect and mammalian cells from the hydrodynamic stress resulting from sparging. This article describes the relevant properties of Pluronic polyols, the ability of Pluronic polyols to protect insect and mammalian cells from sparging and agitation, and the application of Pluronic polyols to cell culture.

Key concepts: Poloxamer, Sparging, Polyol, Chemistry, Cell culture, Chemical engineering, Organic chemistry, Copolymer

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