A Study of Biochemical Changes of Rocuronium Bromide and other Muscle Relaxants in Cardiac Surgery

Introduction: Neuromuscular blockers like Rocuronium bromide can impair respiratory functions during general anaesthesia.Therefore aim of present study was to find out the biochemical changes of Rocuronium bromide and other muscle relaxant in cardiac surgery.Material and Methods: Present study was carried out on sixty (60) patients of different age groups from both sexes scheduled for various cardiac surgical procedures at L.P.S. Institute of Cardiology, GSVM medical college Kanpur during the period of August 1998 to August 1999.Patients were classified in 3 equal groups.Muscle relaxants were given according to the group and biochemical parameters like PCo 2 , PO 2 , pH etc. were recorded carefully at the interval of two, five and ten minutes.Results: No statistically significant changes were observed in PCo 2, pH, Na + , K + at 2 minutes, 5 minutes and 10 minutes after the administration of all three drugs (P >0.05) compared with control values.Statistically Significant changes in PO2 and O2 saturation was observed at 2 minutes, 5 minutes and 10 minutes after the administration of Pancuronium (P <0.05).Conclusion: Rocuronium bromide is safer in cardiac surgery as compared to other muscle relaxants.