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2020•Oxford University Press eBooksRequires access

Cryotherapy for Retinopathy of Prematurity

Alan D. Penman, Kimberly W. Crowder, William M. Watkins

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Abstract

The Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) was a randomized, controlled, interventional clinical trial to determine whether cryotherapy was effective in reducing the unfavorable ocular outcomes from threshold retinopathy of prematurity (ROP). The study showed that at a 3-month assessment, cryotherapy was significantly beneficial for eyes with ROP at a defined threshold level of severity. The findings of the CRYO-ROP study led to the implementation of neonatal screening and peripheral retinal ablation for acute ROP throughout the United States and beyond. Long-term results of CRYO-ROP have also influenced the management of affected patients throughout the remainder of childhood.

About this research paper

What this paper is about

The Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) was a randomized, controlled, interventional clinical trial to determine whether cryotherapy was effective in reducing the unfavorable ocular outcomes from threshold retinopathy of prematurity (ROP). The study showed that at a 3-month assessment, cryotherapy was significantly beneficial for eyes with ROP at a defined threshold level of severity. The findings of the CRYO-ROP study led to the implementation of neonatal screening and peripheral retinal ablation for acute ROP throughout the United States and beyond. Long-term results of CRYO-ROP have also influenced the management of affected patients throughout the remainder of childhood.

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Available abstract

The Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) was a randomized, controlled, interventional clinical trial to determine whether cryotherapy was effective in reducing the unfavorable ocular outcomes from threshold retinopathy of prematurity (ROP). The study showed that at a 3-month assessment, cryotherapy was significantly beneficial for eyes with ROP at a defined threshold level of severity. The findings of the CRYO-ROP study led to the implementation of neonatal screening and peripheral retinal ablation for acute ROP throughout the United States and beyond. Long-term results of CRYO-ROP have also influenced the management of affected patients throughout the remainder of childhood.

Key concepts: Cryotherapy, Retinopathy of prematurity, Medicine, Randomized controlled trial, Clinical trial, Ophthalmology, Surgery, Gestational age

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