Demethylation of Tumor Suppressor Genes In Leukemia By Using Natural Compounds

Leukemia is a type a malignant neoplastic disease containing blood-forming tissue, including blood in addition to the lymphatic system. They are many sub-categories of blood cells containing platelets, white blood cells (WBCs) and red blood cells (RBCs). In general leukemia refers to cancer in reference to leucocytes or WBCs. There are some risk factors of leukemia- smoking increases the risk in developing the acute myeloid leukemia (AML), gene-transmitted disease, exposure to radiation. The general symptoms of leukemia are dehydrating (vomiting, sweating), causeless weight loss, bone pain, headache, pandemonium, lack of sphincter muscle command and involuntary movements. According worldwide report leukemia constitutes approximately 14.1% of one lakhs population out of which 6.5% turns out is death cases. Leukemia occurs in adults above 55 years and children younger than 15 years. In India there are 10,000 cases of childhood leukemia has been reported. Leukemia in Indian prenatal subpopulation appears ultimate 34%, whichever 25% acute lymphocytic leukemia (ALL). In India the total cases of leukemia were found to be 10 lakhs   every year out of which 30,000 cases are of acute leukemia (Ref.). This review focusses on booking agent of hypermethylation that plays an important role in the translocation of Tumor suppressor genes in leukemia. Epigenetic alternations are reversible modifications in histone or DNA hypermethylation that regulate gene utilization after the underlying sequence. Another focus may be Reversal of Hypermethylation of Tumor Suppressor genes (TSGs) in Leukemia using natural compounds. Recent findings have shown great potential of alternative interventions such as immunotherapy and natural products for leukemia.