CИНДРОМ ИЗБЫТОЧНОГО БАКТЕРИАЛЬНОГО РОСТА ТОНКОЙ КИШКИ У ДЕТЕЙ С ХРОНИЧЕСКОЙ ГАСТРОДУОДЕНАЛЬНОЙ ПАТОЛОГИИ, АССОЦИИРОВАННОЙ С Helicobacter pylori

Recent studies suggest a potential relationship between Helicobacter pylori (HP) infection and small intestinal bacterial overgrowth (SIBO). The state of the digestive tract microflora is not often taken in account in the treatment of children with chronic gastroduodenal pathology (CGDP), associated with HP. Study Aims. To study the frequency of SIBO by using the hydrogen breath test with a load of lactulose in children with CGDP. Methods. The study involved 160 patients with CGDP, aged 12 to 17 years: 60 patients with duodenal ulcer disease (DUD), 50 - with functional dyspepsia (FD), associated with HP and 50 children with FD, not associated with HP. The control group was composed by 30 healthy children. HP infection was detected in patients by the two ways: a rapid urease test with biopsy material and an urea breath test. Diagnosis of SIBO was based on a non-invasive hydrogen breath test with a load of lactulose. Results. SIBO was revealed in 57 (95.0±2.8%) children with DUD and in 37 (74.0±6.2%) patients with FD, associated with HP. SIBO was revealed in 23 (46.0±7.0%) cases in children with FD, not associated with HP. It was not statistically significant (p<0.05) relative to the control group, in which SIBO was revealed only in 4 (13.3±6.2%) children. Conclusions. This study demonstrated the high prevalence of SIBO in patients with CGDP, associated with HP. It can lead to decline efficiency of HP therapy and increased frequency of side effects of this therapy.