2020•JAMA Internal MedicineOpen access

FDA Acceptance of Surrogate End Points for Cancer Drug Approval: 1992-2019

Emerson Yu-sheng Chen, Alyson Haslam, Vinay K. Prasad

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Abstract

This retrospective review assesses the frequency of surrogate measures used for the first time vs subsequent times in a cancer setting and the surrogate’s strength of correlation with patient-centered outcomes.

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This retrospective review assesses the frequency of surrogate measures used for the first time vs subsequent times in a cancer setting and the surrogate’s strength of correlation with patient-centered outcomes.

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OpenAlex reports 124 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

This retrospective review assesses the frequency of surrogate measures used for the first time vs subsequent times in a cancer setting and the surrogate’s strength of correlation with patient-centered outcomes.

Key concepts: Medicine, Surrogate endpoint, Cancer drugs, Retrospective cohort study, Cancer, Drug approval, Drug, Medical physics

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