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2020•Journal of Chemical Society of NigeriaOpen access

Synthesis, Characterization and Bioactivity of N,N’-bis[2-(5-bromo-7-azabenzimidazol-1-yl)-2-oxoethyl]ethylene-1,3-diamine and the –cyclohexyl-1,2-diamine analogue.

Kola A. Oluwafemi

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Abstract

N,N’-bis[2-(5-bromo-7-azabenzimidazol-1-yl)-2-oxoethyl]ethylene-1,3-diamine  and the –cyclohexyl- 1,2-diamine analogue were synthesized from 7-aza-5-bromobenzimidazole. Their effect on human cervix adenocarcinoma cells was examined and the results indicated that the two novel compounds were not cytotoxic. Azabenzimidazoles; Akylation; HeLa cells; Cytotoxicity; NMR

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N,N’-bis[2-(5-bromo-7-azabenzimidazol-1-yl)-2-oxoethyl]ethylene-1,3-diamine  and the –cyclohexyl- 1,2-diamine analogue were synthesized from 7-aza-5-bromobenzimidazole. Their effect on human cervix adenocarcinoma cells was examined and the results indicated that the two novel compounds were not cytotoxic. Azabenzimidazoles; Akylation; HeLa cells; Cytotoxicity; NMR

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Available abstract

N,N’-bis[2-(5-bromo-7-azabenzimidazol-1-yl)-2-oxoethyl]ethylene-1,3-diamine  and the –cyclohexyl- 1,2-diamine analogue were synthesized from 7-aza-5-bromobenzimidazole. Their effect on human cervix adenocarcinoma cells was examined and the results indicated that the two novel compounds were not cytotoxic. Azabenzimidazoles; Akylation; HeLa cells; Cytotoxicity; NMR

Key concepts: Diamine, Ethylene diamine, HeLa, Cytotoxicity, Chemistry, Medicinal chemistry, Organic chemistry, Nuclear chemistry

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Synthesis, Characterization and Bioactivity of N,N’-bis[2-(5-bromo-7-azabenzimidazol-1-yl)-2-oxoethyl]ethylene-1,3-diamine and the –cyclohexyl-1,2-diamine analogue. — Research Paper | ScholarLens