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2019•Turkish Journal of Internal MedicineOpen access

Effect of conversion from azathioprine to mycophenolate mofetil on renal function in stable kidney transplant recipients

Mehmet Emin Usta, Alparslan Ersoy, Yavuz Ayar

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Abstract

Abstract Aim: This study investigated the effect of mycophenolate mofetil (MPA) treatment instead of azathioprine (AZA) on renal function after kidney transplantation. Methods: Thirteen of all recipients were taking a cyclosporine-based regimen and serum creatinine levels were above 1.5 mg/dL. In 13 patients, MPA treatment was started instead of AZA. Renal functions were evaluated for 12 months after MPA treatment. Results: Serum creatinine levels increased from 2.11±0.48 mg/dL to 2.16±0.72 mg/dL at 12th months. This increase was not statistically significant. Serum creatinine levels decreased in 5 of 13 patients. Conclusion: In selected patients, conversion from AZA to MPA may slow down the rate of deterioration in graft functions.

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Abstract Aim: This study investigated the effect of mycophenolate mofetil (MPA) treatment instead of azathioprine (AZA) on renal function after kidney transplantation. Methods: Thirteen of all recipients were taking a cyclosporine-based regimen and serum creatinine levels were above 1.5 mg/dL. In 13 patients, MPA treatment was started instead of AZA. Renal functions were evaluated for 12 months after MPA treatment. Results: Serum creatinine levels increased from 2.11±0.48 mg/dL to 2.16±0.72 mg/dL at 12th months. This increase was not statistically significant. Serum creatinine levels decreased in 5 of 13 patients. Conclusion: In selected patients, conversion from AZA to MPA may slow down the rate of deterioration in graft functions.

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Available abstract

Abstract Aim: This study investigated the effect of mycophenolate mofetil (MPA) treatment instead of azathioprine (AZA) on renal function after kidney transplantation. Methods: Thirteen of all recipients were taking a cyclosporine-based regimen and serum creatinine levels were above 1.5 mg/dL. In 13 patients, MPA treatment was started instead of AZA. Renal functions were evaluated for 12 months after MPA treatment. Results: Serum creatinine levels increased from 2.11±0.48 mg/dL to 2.16±0.72 mg/dL at 12th months. This increase was not statistically significant. Serum creatinine levels decreased in 5 of 13 patients. Conclusion: In selected patients, conversion from AZA to MPA may slow down the rate of deterioration in graft functions.

Key concepts: Mycophenolate, Azathioprine, Creatinine, Medicine, Renal function, Urology, Regimen, Kidney

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Effect of conversion from azathioprine to mycophenolate mofetil on renal function in stable kidney transplant recipients — Research Paper | ScholarLens