Features of methods of glomerular filtration rate estimation

A decrease in glomerular filtration rate (GFR) is an earlier sign of detection of chronic kidney diseases compared to an increase in urea and blood creatinine concentrations. It is impossible to measure the glomerular filtration rate directly. GFR is determined by calculating the concentration of blood creatinine or by measuring the clearance of endogenous creatinine. The work shows the influence of methods for the determination of creatinine on the results of the calculation of glomerular filtration rate and terms for the correct choice of method of measuring glomerular filtration rate in different clinical situations associated with chronic kidney disease.