COMPARATIVE STUDY OF ANTI-INFLAMMATORY EFFECT OF DICLOFENAC AND ETORICOXIB ON PATIENTS WITH INFLAMED KNEE JOINT

Non steroidal anti-inflammatory drugs are non-narcotic or non opioid analgesics.Various exogenous and endogenous stimuli incite a complex reaction in vascularized connective tissue called inflammation. Preferential COX-2 inhibitors named diclofenac and Selective COX-2 inhibitor named etoricoxib was taken for my present work and anti inflammatory effect was compared with control and with each other. Student-t-test-was done to compare result. It was found that inflammation varied significantly across the three groups (P=.000) Compared to control, inflammation was less in both diclofenac and etoricoxib (P=.00). Reduction of inflammation with diclofenac was less, in comparison to etoricoxib at end. Etoricoxib is more efficacious than diclofenac. Keywords: Etoricoxib, Diclofenac, Anti inflammatory effect.