Synthesis and NMR Characterization of New Isatin Sulfonic Acid Thiosemicarbazone Compounds

This work shows the synthesis and characterization of a series of isatin sulfonic acid thiosemicarbazone compounds, based on the 5-isatin-3-sulfonic acid (ISA) substrate. After synthesis and purification, the 1H NMR and 13C NMR spectra were obtained using a 500 MHz NMR spectrometer. Experimental data was observed using 2D NMR techniques, such as, HSQC (heteronuclear single quantum coherence) 1H-13C NMR and HSQC 1H-15N NMR to give evidence for the structures of these new compounds.