2020•PubMedRequires access

[Effect of electroacupuncture on the P35/P25-cyclin-dependent kinase 5-Tau pathway in hippocampus of rats with Alzheimer's disease].

Yi Ying Wang, Meng Gao, Guo Ping Qiu, Jin Xu, Yan Jun Wu, Yi Xu, Jian Rong Wang, Hua Jun Sheng, Shu Zhu

Abstract

OBJECTIVE: To investigate the effect of electroacupuncture on the P35/P25-cyclin-dependent kinase 5 (CDK5)-Tau pathway in rats with Alzheimer's disease (AD), as well as the mechanism of electroacupuncture in the prevention and treatment of AD. METHODS: into the bilateral hippocampus. The rats in the electroacupuncture treatment group were given electroacupuncture at "Baihui" (GV20) and "Shenshu" (BL23) once a day, 15 min each time, for 10 days. Morris water maze was used to evaluate learning and memory abilities, immunohistochemistry was used to measure the distribution and expression of P35/P25, CDK5, and Tau5 in the hippocampus, and Western blot was used to measure the expression of the above mentioned proteins, phosphory-lated Tau(Ser199, Ser202). RESULTS: <0.01). CONCLUSION: Electroacupuncture may delay the progression of AD by affecting the expression of proteins involved in the P35/P25-CDK5-Tau pathway in the hippocampus of rats.

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Key concepts: Electroacupuncture, Medicine, Morris water navigation task, Hippocampus, Immunohistochemistry, Cyclin-dependent kinase 5, Internal medicine, Latency (audio)