EVALUATION OF HEPATOPROTECTIVE POTENTIAL OF RAPHANUS SATIVUS (FAMILY: BRASSICACEAE) ROOT AGAINST ACETAMINOPHEN INDUCED HEPATOTOXICITY IN EXPERIMENTAL RATS

The present study was conducted to evaluate hepatoprotective potential of ethanol extract from Raphanus sativus root (ERS).Hepatoprotective potential of ERS was tested at doses of 100, 200 and 400 mg/kg (p.o.), against acetaminophen (paracetamol) induced hepatotoxicity in rats.The ERS at different doses and silymarin treated animal groups showed significant decrease in levels of different biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamate-pyruvate transaminase (SGPT), and alkaline phosphatase (ALP), that were elevated by acetaminophen intoxication.The levels of total bilirubin, bilirubin direct, bilirubin indirect, total protein, albumin and serum globulin along were also restored to normal by ERS and silymarin treatment.ERS at 400 mg/kg showed significant (P<0.001)result and comparable to silymarin treated group of rats.Histological studies supported the biochemical findings and treatment with ERS at dose level of 100, 200 and 400 mg/kg, p.o. was found to be effective in restoring acetaminophen-induced hepatotoxicity in rats.