2016•PubMedRequires access

[Type 2 innate lymphoid cells and chronic rhinosinusitis].

Congli Geng, Z M Xing

Abstract

Type 2 innate lymphoid cells (ILC2) is a new group of the innate lymphoid cells which has been recently discovered. These cells can produce type 2 cytokines such as interleukin-5 (IL-5) and interleukin-13 (IL-13) on response to interleukin-33 (IL-33), interleukin-25(IL-25) and thymic stromal lymphopoietin (TSLP) to initiate and maintain the type 2 inflammation in human. Nasal polyps from patients with chronic rhinosinusitis (CRS) show enrichment for ILC2, which suggests ILC2 could have a critical role in the occurrence/development of nasal polyps. This review focuses on discovery of ILC2, immunological properties of ILC2 and ILC2 in CRS.

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Available abstract

Key concepts: Innate lymphoid cell, Thymic stromal lymphopoietin, Interleukin 33, Chronic rhinosinusitis, Immunology, Inflammation, Innate immune system, Stromal cell