2020•Frontiers in EndocrinologyOpen access
The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey
Jinjia Zhang, Yiyang Gao, Yongze Li, Di Teng, Yuanming Xue, Li Yan, Jing Yang, Lihui Yang, Yongli Yao, Jianming Ba, Bing Chen, Jianling Du, Lanjie He, Xiaoyang Lai, Xiaochun Teng, Xiaoguang Shi, Yanbo Li, Haiyi Chi, Eryuan Liao, Chao Liu, Libin Liu, Guijun Qin, Yingfen Qin, Huibiao Quan, Bingyin Shi, Hui Sun, Xulei Tang, Nanwei Tong, Guixia Wang, Jin‐an Zhang, Youmin Wang, Zhen Ye, Qiao Zhang, Lihui Zhang, Jun Zhu, Mei J. Zhu, Weiping Teng, Zhongyan Shan, Jing Li
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Abstract
Purpose: The expression of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) are very common in the sera of patients with autoimmune thyroid diseases (AITD). The relationship between thyroid auto-antibodies and the occurrence of glucose and lipid metabolic disorders remains unclear. This study was performed to investigate the correlation between the presence of serum TPOAb/TgAb and those metabolic disorders in euthyroid general population. Methods: The data of this study was derived from the Thyroid Disease, Iodine status and Diabetes National epidemiological (TIDE) survey, a recent national survey. A total of 17964 subjects including 5802 males (4000 with TPOAb-TgAb- and 1802 with TPOAb+/TgAb+) and 12162 females (8000 with TPOAb-TgAb- and 4162 with TPOAb+/TgAb+) were enrolled in this study. The blood glucose and lipid levels were compared between individuals with TPOAb-TgAb- and those with TPOAb+TgAb-, TPOAb-TgAb+, TPOAb+TgAb+, respectively. Results: Both the fasting blood glucose (FBG) concentration and the proportion of individuals with impaired FBG (IFG) showed a decreased trend in TPOAb-TgAb+ males as compared with those TPOAb-TgAb- men. There were significantly lower FBG and higher HDL-C levels as well as tendencies to decreased incidences of IGT and hypertriglyceridemia in the TPOAb-TgAb+ females when compared with those TPOAb-TgAb- women. Binary logistic regression analysis further showed that serum TgAb single positivity in males was an independent protective factor for IFG with an OR of 0.688 (0.501-0.945). For females, serum TgAb single positivity was an independent protective factor for hypertriglyceridemia with an OR of 0.860 (0.749-0.988). Trend test showed that with the increase of serum TgAb level, there was a tendency of decrease in the prevalence of IFG among the men (P for trend=0.064) and that of hypertriglyceridemia in women (P for trend=0.047) who were all euthyroid. Conclusion: Serum TgAb single positivity may imply a reduced risk of IFG in euthyroid men and that of hypertriglyceridemia in euthyroid women. The mechanisms related to these interesting phenomena await further investigation.
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