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2020•Kidney International ReportsOpen access

SUN-377 C3 GLOMERULONEPHRITIS MASQUERADING AS POST-INFECTIOUS GLOMERULONEPHRITIS

Minna Seppälä, Marja Kovala, Anne K Räisänen-Sokolowski, Eero Olavi Honkanen, Seppo Meri, Kati Kaartinen

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Abstract

Post-infectious glomerulonephritis (PIGN) is a self-limiting glomerulonephritis (GN). It manifests as a diffuse endocapillary GN and in immunofluorescence staining (IF) co-deposition of IgG and C3 is commonly seen, as well as C3-dominant glomerular depositions. Classically, there are subepithelial humps on electron microscopy (EM). However, there are reports where the initial histological presentation was PIGN, but the patients turned out to have a chronic C3 glomerulopathy (C3G). The aim of this study was to investigate etiological, histological and clinical factors of these patients.

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What this paper is about

Post-infectious glomerulonephritis (PIGN) is a self-limiting glomerulonephritis (GN). It manifests as a diffuse endocapillary GN and in immunofluorescence staining (IF) co-deposition of IgG and C3 is commonly seen, as well as C3-dominant glomerular depositions. Classically, there are subepithelial humps on electron microscopy (EM). However, there are reports where the initial histological presentation was PIGN, but the patients turned out to have a chronic C3 glomerulopathy (C3G). The aim of this study was to investigate etiological, histological and clinical factors of these patients.

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Available abstract

Post-infectious glomerulonephritis (PIGN) is a self-limiting glomerulonephritis (GN). It manifests as a diffuse endocapillary GN and in immunofluorescence staining (IF) co-deposition of IgG and C3 is commonly seen, as well as C3-dominant glomerular depositions. Classically, there are subepithelial humps on electron microscopy (EM). However, there are reports where the initial histological presentation was PIGN, but the patients turned out to have a chronic C3 glomerulopathy (C3G). The aim of this study was to investigate etiological, histological and clinical factors of these patients.

Key concepts: Glomerulopathy, Glomerulonephritis, Medicine, Pathology, Immunofluorescence, Renal biopsy, Limiting, Etiology

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