More than flipping the lid: Cdc50 contributes to echinocandin resistance by regulating calcium homeostasis in Cryptococcus neoformans

More than flipping the lid: Cdc50 contributes to echinocandin resistance by regulating calcium homeostasis in Cryptococcus neoformans – Cryptococcus neoformans is an invasive fungal pathogen that often causes deadly cryptococcal meningitis, especially in immunocompromised individuals. Despite the disease's clinical importance, its treatment options remain quite limited. The two major antifungal drugs for treating cryptococcosis are either toxic (amphotericin B) or fungistatic (azoles). Echinocandins represent the recent third antifungal drug class that targets β-1,3-glucan (...)