2020•PubMedRequires access

[Effects of dexmedetomidine on injury of lungs and CHOP protein expression in elderly patients with lung cancer during one-lung ventilation].

G C Liu, Kai Sun, Haoyu Fu, Tieli Dong, Fang Yuan

Abstract

Dexmedetomidine could attenuate the extent of lung injury in elderly patients with lung cancer undergoing thoracoscopic lobectomy. The pulmonary protective mechanism could be related to the inhibition of inflammatory factors in dexmedetomidine, improving oxidative stress and reducing Chop-mediated apoptosis of lung tissue by the protein.

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Available abstract

Key concepts: Medicine, Anesthesia, Lung cancer, Dexmedetomidine, CHOP, Lung, Ventilation (architecture), Gastroenterology