A Study of Hemodynamic Effects of Rocuronium Bromide and other Muscle Relaxants in Cardiac Surgery

Introduction: Use of muscle relaxants in cardiac surgery poses a challenge to anaesthesia due to narrow margin of safety and limited cardiovascular function.Therefore aim of present study is to find out the hemodynamic effects of Rocuronium bromide and other muscle relaxant in cardiac surgery.Material and Methods: Present study was carried out on sixty (60) patients of different age groups from both sexes scheduled for various cardiac surgical procedures at L.P.S. Institute of Cardiology, GSVM medical college Kanpur during the period of August 1998 to August 1999.Patients were classified in 3 equal groups.Muscle relaxants were given according to the group and hemodynamic parameters were recorded carefully at the interval of two, five and ten minutes.Results: No statistically significant changes were observed in systolic blood pressure, diastolic blood pressure and central venous pressure at 2 minutes, 5 minutes and 10 minutes after the administration of all three drugs (P >0.05) compared with control values.Significant increase in heart rate was observed at 2 minutes and 5 minutes after the administration of Pancuronium (P <0.05).Conclusion: On basis of present study's result, it can be said that Rocuronium bromide is safer in cardiac surgery as compared to Vecuronium & Pancuronium.