THE EFFECT OF LOCAL APPLICATION OF BISPHOSPHONATES IN OSSEOINTEGRATION OF DENTAL IMPLANT: AN EXPERIMENTAL STUDY

Objectives: Bisphosphonates are reported to enhance osseointegration of dental implant and inhibit osteoclast activity. However, few studies evaluated the effect of local application of bisphosphonate in implant osseointegration.Purpose: This study was conducted to evaluate the effect of local application of bisphosphonate on osseointegration of dental implant. Materials and methods: Twenty New Zealand white rabbits with average weight (2.5kg -4kg) were included in this study. All rabbits randomly divided into two groups; control group (n=10 rabbits) and study group (n=10 rabbits). The dental implant was inserted in tibia of both groups with addition of bisphosphonate which locally applied in osteocyte socket of study group only. All animals would scarified after 29 days. Histomorphometric and histological analysis were done . Results: Histological evaluation showed an increase in new bone formation and bone implant contact in study group with statistically significant difference (P value 0.001) .Conclusion: Local application of bisphosphonates enhances osseointegration of dental implant.