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2017•PubMedOpen access

Increased expression of kidney injury molecule-1 and matrix metalloproteinase-3 in severe Plasmodium falciparum malaria with acute kidney injury.

Chuchard Punsawad, Parnpen Viriyavejakul

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Abstract

< 0.001). There was a significant positive correlation of total score of KIM-1 expression and the parameters of kidney function for AKI, including serum creatinine (Cr) and blood urea nitrogen (BUN). In addition, strong positive correlations were found between total score of KIM-1 expression and proximal tubular necrosis and MMP-3 expression. The study supports the potential role of KIM-1 as a specific biomarker for renal proximal tubular damage in malarial AKI, and indicates that the process of KIM-1 shedding might be stimulated by MMP-3.

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< 0.001). There was a significant positive correlation of total score of KIM-1 expression and the parameters of kidney function for AKI, including serum creatinine (Cr) and blood urea nitrogen (BUN). In addition, strong positive correlations were found between total score of KIM-1 expression and proximal tubular necrosis and MMP-3 expression. The study supports the potential role of KIM-1 as a specific biomarker for renal proximal tubular damage in malarial AKI, and indicates that the process of KIM-1 shedding might be stimulated by MMP-3.

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Available abstract

< 0.001). There was a significant positive correlation of total score of KIM-1 expression and the parameters of kidney function for AKI, including serum creatinine (Cr) and blood urea nitrogen (BUN). In addition, strong positive correlations were found between total score of KIM-1 expression and proximal tubular necrosis and MMP-3 expression. The study supports the potential role of KIM-1 as a specific biomarker for renal proximal tubular damage in malarial AKI, and indicates that the process of KIM-1 shedding might be stimulated by MMP-3.

Key concepts: Acute kidney injury, Creatinine, Kidney, Blood urea nitrogen, Biomarker, Medicine, Immunohistochemistry, Malaria

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Increased expression of kidney injury molecule-1 and matrix metalloproteinase-3 in severe Plasmodium falciparum malaria with acute kidney injury. — Research Paper | ScholarLens