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2020•NanoscaleOpen access

Iron-mediated interaction of alpha synuclein with lipid raft model membranes

Fabio Perissinotto, Chiaramaria Stani, Elena De Cecco, Lisa Vaccari, Valeria Rondelli, Paola Posocco, Pietro Parisse, Denis Scaini, Giuseppe Legname, Loredana Casalis

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Abstract

We demonstrated that pathological conditions as accumulation of iron cations promote fast formation of α-synuclein aggregation in vitro , which preferentially interact with lipid-raft domains in model cell membrane systems.

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We demonstrated that pathological conditions as accumulation of iron cations promote fast formation of α-synuclein aggregation in vitro , which preferentially interact with lipid-raft domains in model cell membrane systems.

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OpenAlex reports 22 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

We demonstrated that pathological conditions as accumulation of iron cations promote fast formation of α-synuclein aggregation in vitro , which preferentially interact with lipid-raft domains in model cell membrane systems.

Key concepts: Raft, Membrane, Lipid raft, Chemistry, In vitro, Biophysics, Cell biology, Biochemistry

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