Is furosemide eenmaal daags wel zinvol?: Literatuurstudie naar rationale achter dosering van kortwerkend diureticum

•Furosemide is a widely used shortacting diuretic with a steep doseresponse curve. •Furosemide is commonly prescribed once daily, but because of its shortacting nature it is questionable if a oncedaily regiment is effective. •Different physiological and pathophysiological principles influence the effect and period of efficacy of furosemide. •Studies in both healthy subjects and different patient categories do demonstrate efficacy of furosemide once daily, but also that furosemide prescribed twice daily is more effective. •It is advised to combine furosemide treatment with a sodiumrestricted diet, because this enhances the effects of the diuretic treatment.